From a structural standpoint, the inner seal should need see a lot of stress. The silicone in the joints should be holding the glass together - thus the inner seal should see minimal or no tensile stress.
Theoretically, if the seams are completely siliconed, you should not need the inner silicone. We all know what theory is worth in the real world...you will probably have tiny gaps in the joints. Due to the pressure and stretching, the water will leak out. The inner seal is more robust in assuring no gaps - you can see it.
A belt and suspenders is a practical approach, especially in this size tank.
One thing I have read (for entertainment I looked at building a tank) is that you need to silicone all at once since silicone does not bond well to itself once it cures......this to me is the major obstacle in builing your own tank or resealing your own.