I feed them regulary to my fish, mostly livebearers and Cory catfish but also to my West African Cichlids. I have never had a problem with them but I know someone at the local store where I buy them that will not even touch the package to scan them. The only brand that I purchase are are Hikari BioPure. 8 years of using them and no issues, however, I am not touching them either. I pop them out of the tray into a glass and then add water to thaw them. No touching and I normally wash my hands afterwords, so no problems, at least for now.